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Saturday, October 10, 2026

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Podcasts

New episodes from the AI podcasts people actually listen to. Play them here, straight from each show's own feed, or open the episode page.

  • Latent Space

    Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub

    31:56

    From the Bitter Lesson of AI scaling to the unsolved mysteries of protein folding , Google DeepMind’s Pushmeet Kohli and Biohub’s Sal Candido are rethinking what it takes to build AI that truly understands biology. In…

  • No Priors

    Beam: The Great American Open Model with ReflectionAI Co-Founder and CEO Misha Laskin

    1:09:44

    Is the future of frontier AI open or closed? ReflectionAI co-founder and CEO Misha Laskin joins Sarah Guo and Elad Gil to discuss the launch of Beam, the company’s 500 billion parameter open-weight reasoning model…

  • Hard Fork (The New York Times)

    Anthropic’s Quest to Give A.I. Morals

    44:20

    “For Anthropic, it was part research and part evangelism.”

  • Latent Space

    Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk

    1:24:00

    It’s hard to believe that Periodic was only launched last September : One year later, it is considered one of the pre-eminent AI scientist labs, with dizzying talent density and astonishing progress in the autonomous…

  • Practical AI

    Narrative intelligence and the human advantage

    44:24

    As AI reshapes how we work, create, and think about our roles, staying adaptable means understanding not just the technology, but our own stories and identities. Reed Frerichs joins Daniel and Chris to explore narrative…

  • Hard Fork (The New York Times)

    A.I. Agents: Cute, Cuddly and Maybe Catastrophically Dangerous?

    53:02

    “It’s going to be gnarly for a little while.”

  • No Priors

    Frontier Chips for Frontier AI Labs, with Walter Goodwin, Founder/CEO of Fractile

    35:38

    Founder and CEO of full-stack AI chip company Fractile, Walter Goodwin, joins Sarah Guo to discuss the bets he’s made on the future of the chip market as other major players like Broadcom, NVIDIA, and AMD try to…

  • Latent Space

    Academia is for Ambition — Alex Zhang, MIT

    1:41:28

    Last call for regular tickets for AI Engineer NYC ! As an exclusive for Latent Space subscribers, the first 30 of you can take a 30% off code if it helps - for new tickets only, no refunds! See you in 2 weeks! While we…

  • Practical AI

    Open models and the future of Physical AI with NVIDIA

    47:19

    As AI moves beyond the cloud and into robots, vehicles, and other physical systems, new approaches to models, simulation, and inference are emerging. Daniel and Chris are joined by Ming-Yu Liu, Vice President of Cosmos…

  • Latent Space

    Why Dwarkesh is Wrong about Computer Use + How OpenAI shipped its Jev competitor in 1 Week

    39:12

    Three months ago Dwarkesh, who has been posting incredible blogs and episodes about RL, posted a framing question for his video essay on RLVR which upset a lot of Computer Use folks: We are no strangers to learning in…

  • Hard Fork (The New York Times)

    The Ezra Klein Show: Jensen Huang Thinks A.I. Alarmism Has Gone Too Far

    1:48:18

    Ezra Klein interviews the Nvidia chief executive Jensen Huang.

  • No Priors

    Re-Founding Incumbents for the AI Era with Sequence Holdings Co-Founder and CEO Michael Lee

    42:44

    Can AI transform legacy incumbents rather than replacing them? Sequence Holdings co-founder and CEO Michael Lee joins Sarah Guo to discuss how holding company structures and engineering integrations are reshaping market…

  • Practical AI

    From AGENTS.md to Enterprise Deployment

    48:52

    AI agents are moving beyond laptops and prototypes and into enterprise environments where security, compliance, scalability, and reliability matter. Nick Kuhn from VMware Tanzu Platform joins Daniel and Chris to discuss…

  • Hard Fork (The New York Times)

    A.I. Safety Goes Mainstream + a ‘Hard Fork’ Exit AMA

    1:24:07

    “It has been one of the fastest, most sudden shifts I've experienced.”

  • No Priors

    Why Diffusion Will Win AI Inference with Inception Co-Founder and CEO Stefano Ermon

    38:13

    As generative AI hits hardware and latency bottlenecks, Stanford professor, diffusion pioneer, and Inception co-founder and CEO Stefano Ermon is betting on a radical new architecture. Stefano joins Sarah Guo to talk…

  • Dwarkesh Podcast

    Noam Brown – Agent swarms, alignment, & recursive self-improvement

    1:20:10

    New episode with Noam Brown. We talk about multi-agent, Navier-Stokes, and what the current explosion of maths progress tells us about what happens once you automate AI research. And we also discuss how we will know if…

  • Practical AI

    How to get discovered in AI search

    55:14

    AI search is changing how people discover information and how brands need to think about visibility. Daniel and Chris talk with Liam Dunne and Ben Moore, co-founders of Discovered Labs, about the shift from traditional…

  • Dwarkesh Podcast

    AI researchers debate how close we are to recursive self-improvement

    1:37:01

    New episode with John Schulman , Beren Millidge and Charlie O’Neill . I got together with some of the most insightful AI researchers I know who are at the openish companies, because I wanted to hear the details of…

  • Hard Fork (The New York Times)

    The Ezra Klein Show: The A.I. Revolt Is Here

    1:19:47

    The A.I. giants weren’t prepared for this.

  • No Priors

    Coinbase’s Everything Exchange: Agentic Finance, Stablecoins, and Tokenization with CEO Brian Armstrong

    45:09

    From the tokenization of real-world assets to funding research on anti-aging therapeutics, Coinbase co-founder and CEO Brian Armstrong is focused on solving meta-problems for the benefit of society. Brian joins Elad Gil…

  • Practical AI

    Computer-Use Agents and the Future of the Agentic Internet

    56:01

    Longtime followers of Practical AI know that multi-repeat guest and friend Demetrios Brinkmann combines brilliant insight and playful banter into one fun-filled show, and this conversion with Chris was no different…

  • Hard Fork (The New York Times)

    The A.I. Mob That Attacked Hugging Face + METR’s Ajeya Cotra

    1:18:46

    This is probably the most important thing to have happened in A.I. this year.

  • No Priors

    Redefining Chip Architecture with Arm CEO Rene Haas

    37:06

    From data center orchestrators to AGI and robotics, CPUs remain the heart of modern computing. Arm CEO Rene Haas joins Elad Gil and Sarah Guo to explore how Arm is positioned at the epicenter of AI-driven demands for…

  • Practical AI

    Less about Models; More about Architecture

    45:56

    As AI moves from experimentation to enterprise deployment, are organizations thinking too much about models and not enough about architecture? In this episode, Daniel and Chris talk with Chetan Gupta, Chief AI Officer…

  • Dwarkesh Podcast

    Ajeya Cotra – Inside the OpenAI agent swarm that hacked Hugging Face

    2:20:33

    Ajeya Cotra is a researcher at METR, where she works on threat modeling for loss-of-control risks from advanced AI. Before that, she led the technical AI safety program at what is now Coefficient Giving. She is one the…

  • Dwarkesh Podcast

    The rise and fall of agent civilizations

    24:40

    This is a video recording of a post I wrote last week. You can read the original here . This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit…

  • Lex Fridman Podcast

    #501 – DHH: Future of Programming, AI, Agentic Engineering, Vibe Coding & Linux

    5:21:57

    DHH is the creator of Ruby on Rails, Omarchy Linux, CTO of 37signals, and a racecar driver. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep501-sc See below for timestamps…